Cyclic Variation of Free Aminoacids of Human. Endometrium in Relation to Dysfunctional Uterine Bleeding

The endometrium is one of the most dynamic structures in the human body characterised hy a complete life cycle within a short span of time. Although there can be no doubt about the role of estrogen in promoting endometrial growth and progesterone in influencing the differentiation, yet little is known of the mechanisms by which such changes are accomplished. Behind the constantly changing structure of the normal endometrium lies fundamental biochemical changes in the endometrium which can be expected to lead to a better understand~ ing of its functional and structural changes. Radioactive glycine and other aminoacids (Mureller et al, 1953) are very quickly incorporated into the uterine tissue under the influence of estradiol (Mureller, 1953, 1957, Mureller et al, 1961). Estrogen thus seems to stimulate protein anabolism an the human endometrium, the same situation exists as in